Weight loss specialists recommend using Contrave diet drug for anti-obesity therapy. This prescription weight loss drug contains 2 active ingredients – Naltrexone Hydrochloride and Bupropion Hydrochloride.

Both active substances are psychotropic drugs that act on the CNS and relieve mental state of a patient who decided to change his habits and lifestyle.

In 2011, the FDA asked Orexigen manufacturing company to provide the information about safety of the drug.

  • During clinical trials, it was found that Contrave has high efficiency in regulation of appetite, so the FDA experts were satisfied with the trials results, published in the end of 2013.

Despite the fact that usually Contrave diet pills are well tolerated by patients, this appetite suppressant means can cause side effects. According to patients’ reviews, common side effects go away within the first few weeks of use.

The most common Contrave side effects are:

  • nausea
  • diarrhea
  • headache
  • dizziness
  • vomiting
  • dry mouth
  • constipation
  • trouble sleeping

However, apart from minor side effects, the weight loss drug can cause some serious side effects as well. There are cases, when Bupropion active ingredient caused suicidal behavior in patients.


Bupropion can increase the risk of suicidal thoughts in men and women during the first months of treatment. Usage of Contrave during depression or any other mental disorder may worsen a patient’s state, especially in the beginning of the treatment course.

Serious Contrave side effects are considered the following mental disorders of a patient:

  • anger
  • psychosis
  • paranoia
  • hostility
  • hallucinations
  • anxiety
  • mood swings

In addition, Bupropion may cause seizures.

The risk of seizures depends on the dose of the drug a patient is taking. Specialists do recommend sticking to the prescribed daily dosage, which must never outweigh 360 mg of Bupropion per day.

Some patients may have palpitations and high blood pressure during anti-obesity therapy. Before to begin using Contrave, patients should measure their blood pressure and systematically monitor it throughout the treatment course.

During clinical trials, a small number of patients had allergic reactions in the form of dyspnea, pruritus, angioedema and urticaria.

Often, when people use antidepressants, including Bupropion, they have pupillary dilation, which may cause angle-closure glaucoma in patients with anatomically narrow angles.

The symptoms of this disease include redness or swelling around the eye, eye pain and changes in vision. Patients need to consult a doctor if they have any of these symptoms and side effects.

Comments are closed.